Enzymatic conversion of 7-hydroxyguanine to its nucleosides.

نویسندگان

  • M Kitahara
  • K Ishii
  • T Okazaki
  • T Hidaka
  • K Watanabe
چکیده

7-Hydroxyguanine, an antitumor purine-analog, reacted with ribose (or deoxyribose)-1-phosphate in the presence of purine nucleoside phosphorylase. We prepared 7-hydroxyguanine riboside and deoxyriboside using purine nucleoside phosphorylase from bovine spleen. Each nucleoside exhibits antitumor activity against mouse leukemia L1210 cells. The therapeutic effect of 7-hydroxyguanine deoxyriboside is superior to those of 7-hydroxyguanine and 7-hydroxyguanine riboside.

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منابع مشابه

Preparation of new 7-hydroxyguanine derivatives and their biological activities.

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عنوان ژورنال:
  • The Journal of antibiotics

دوره 39 9  شماره 

صفحات  -

تاریخ انتشار 1986